Ifng^tm1.1Hayg
Targeted Allele Detail

Summary

• Symbol: Ifng^tm1.1Hayg
• Name: interferon gamma; targeted mutation 1.1, Howard A Young
• MGI ID: MGI:5751448
• Synonyms: ARE-del
• Gene: Ifng Location: Chr10:118276951-118281797 bp, + strand Genetic Position: Chr10, 66.75 cM
• Alliance: Ifng^tm1.1Hayg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220784
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced 162 nt of the adenylate-uridylate rich element (ARE) sequence. Cre-mediated recombination removed the neo cassette. Deletion of the ARE increases the half-life of the mRNA and results in constitutive expression of a low level of IFN-gamma under normal physiologic conditions. (J:220784)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifng Mutation: 49 strains or lines available

References

• Original: J:220784 Lin FC, et al., IFN-gamma causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation. Blood. 2014 Dec 11;124(25):3699-708
• All: 16 reference(s)