Cyfip1^tm1Yhj
Targeted Allele Detail

Summary

• Symbol: Cyfip1^tm1Yhj
• Name: cytoplasmic FMR1 interacting protein 1; targeted mutation 1, Yong-hui Jiang
• MGI ID: MGI:5751466
• Gene: Cyfip1 Location: Chr7:55491556-55582381 bp, + strand Genetic Position: Chr7, 33.42 cM, cytoband B5
• Alliance: Cyfip1^tm1Yhj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229098
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: An integration vector consisting of a MICER clone containing 8.3 kb genomic fragment containing exon 5 of Cyfip1, a puromycin selectable cassette, agouti coat color maker, and the 3' half of HPRT was inserted upstream of exon 5. (J:229098)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyfip1 Mutation: 74 strains or lines available

References

• Original: J:229098 Chung L, et al., Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice. Brain Res. 2015 Dec 10;1629:340-50
• All: 1 reference(s)