Mir34a^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm1.2Arte
• Name: microRNA 34a; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:5751473
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and F3-flanked puromycin resistance cassette were inserted upstream of the microRNA sequence. A second loxP site and an FRT-flanked neomycin resistance cassette were inserted downstream of the microRNA sequence. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the microRNA sequence floxed. (J:221990)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 9 strains or lines available

References

• Original: J:221990 Thor T, et al., MiR-34a deficiency accelerates medulloblastoma formation in vivo. Int J Cancer. 2015 May 15;136(10):2293-303
• All: 1 reference(s)