Vps25^m1Lis
Chemically induced Allele Detail

Summary

• Symbol: Vps25^m1Lis
• Name: vacuolar protein sorting 25; mutation 1, Licia Selleri
• MGI ID: MGI:5751483
• Synonyms: 04-014, Vps25^ENU
• Gene: Vps25 Location: Chr11:101144533-101150375 bp, + strand Genetic Position: Chr11, 64.48 cM
• Alliance: Vps25^m1Lis page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transition in intron 3 that results in an in-frame 27 nucleotide insertion encoding 9 additional neutral amino acids. Western blot anlaysis confirmed reduced protein expression in E10.5 embryos. (J:223082)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps25 Mutation: 15 strains or lines available

References

• Original: J:223082 Handschuh K, et al., ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell Rep. 2014 Oct 23;9(2):674-87
• All: 2 reference(s)