Iqcf1^em1Zdq
Endonuclease-mediated Allele Detail

Summary

• Symbol: Iqcf1^em1Zdq
• Name: IQ motif containing F1; endonuclease-mediated mutation 1, Zhongdong Qiao
• MGI ID: MGI:5751515
• Gene: Iqcf1 Location: Chr9:106377166-106379449 bp, + strand Genetic Position: Chr9, 57.65 cM, cytoband F1
• Alliance: Iqcf1^em1Zdq page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN technology was used to generate an 8 bp deletion that results in a premature termination site and loss of an Hpy166II site. Western blot analysis confirmed the absence of protein expression in spermatozoa. (J:228595)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iqcf1 Mutation: 7 strains or lines available

References

• Original: J:228595 Fang P, et al., A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Andrology. 2015 Mar;3(2):332-44
• All: 1 reference(s)