Clk2^tm1.1Ppgr
Targeted Allele Detail

Summary

• Symbol: Clk2^tm1.1Ppgr
• Name: CDC-like kinase 2; targeted mutation 1.1, Pere Puigserver
• MGI ID: MGI:5751695
• Synonyms: Clk2^flox
• Gene: Clk2 Location: Chr3:89072102-89084228 bp, + strand Genetic Position: Chr3, 39.01 cM
• Alliance: Clk2^tm1.1Ppgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229283
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 2 was floxed. Flp-mediated recombination removed the selection cassette. (J:229283)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clk2 Mutation: 38 strains or lines available

References

• Original: J:229283 Tabata M, et al., Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1alpha and MED1 complex. Diabetes. 2014 May;63(5):1519-32
• All: 3 reference(s)