Pcare^tm1Kpal
Targeted Allele Detail

Summary

• Symbol: Pcare^tm1Kpal
• Name: photoreceptor cilium actin regulator; targeted mutation 1, Krzysztof Palczewski
• MGI ID: MGI:5751702
• Synonyms: BC^-
• Gene: Pcare Location: Chr17:72050919-72059904 bp, - strand Genetic Position: Chr17, 42.67 cM
• Alliance: Pcare^tm1Kpal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220866
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette via homologous recombination. qRT-PCR confirmed a virtually complete lack of RNA transcripts in the eyes of homozygous mutant mice. (J:220866)

Disease models

Expression

In Mice Carrying this Mutation:	52018 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcare Mutation: 39 strains or lines available

References

• Original: J:220866 Kevany BM, et al., Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Hum Mol Genet. 2015 May 1;24(9):2627-40
• All: 3 reference(s)