Atoh1^{tm1.1(cre)Jbr}
Targeted Allele Detail

Summary

• Symbol: Atoh1^{tm1.1(cre)Jbr}
• Name: atonal bHLH transcription factor 1; targeted mutation 1.1, Jean-Francois Brunet
• MGI ID: MGI:5751770
• Synonyms: Atoh1^Cre
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^{tm1.1(cre)Jbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229254
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Atoh1^{tm1.1(cre)Jbr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atoh1 (MGI:104654)

• Mutation details: The targeting construct inserted into the 3' UTR downstream of the stop codon an FRT-flanked neomycin resistance cassette, IRES sequence, cre recombinase gene and bovine growth hormone polyadenylation sequence. Flp-mediated recombination removed the selection cassette. (J:229254)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Alliance mouse Atoh1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 37 strains or lines available

References

• Original: J:229254 Ruffault PL, et al., The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO(2). Elife. 2015;4
• All: 2 reference(s)