Dpysl3^tm1Gosh
Targeted Allele Detail

Summary

• Symbol: Dpysl3^tm1Gosh
• Name: dihydropyrimidinase-like 3; targeted mutation 1, Yoshio Goshima
• MGI ID: MGI:5751828
• Synonyms: CRMP4-KO
• Gene: Dpysl3 Location: Chr18:43454049-43571351 bp, - strand Genetic Position: Chr18, Syntenic
• Alliance: Dpysl3^tm1Gosh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226894
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exon 4. Western blot analysis confirmed the absence of protein expression in the brain. (J:226894)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpysl3 Mutation: 45 strains or lines available

References

• Original: J:226894 Niisato E, et al., CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. Dev Neurobiol. 2012 Nov;72(11):1447-57
• All: 10 reference(s)