Tg(Prnp-rtTA2S*M2)#Rkhu
Transgene Detail

Summary

• Symbol: Tg(Prnp-rtTA2S*M2)#Rkhu
• Name: transgene insertion, Renate K Hukema
• MGI ID: MGI:5751867
• Synonyms: Prp-rtTA
• Transgene: Tg(Prnp-rtTA2S*M2)#Rkhu Location: unknown
• Alliance: Tg(Prnp-rtTA2S*M2)#Rkhu page

Transgene origin

• Strain of Origin: C57BL/6JRj

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The prion protein promotor drives the expression of the rtTA2S-M2 variant in the central nervous system (both neurons and glia cells). (J:224760)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:224760 Hukema RK, et al., Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. 2015 Sep 1;24(17):4948-57
• All: 3 reference(s)