Tg(IghH280)48Dvs
Transgene Detail

Summary

• Symbol: Tg(IghH280)48Dvs
• Name: transgene insertion 48, David V Serreze
• MGI ID: MGI:5752045
• Synonyms: PerH
• Transgene: Tg(IghH280)48Dvs Location: unknown
• Alliance: Tg(IghH280)48Dvs page

Transgene origin

• Strain of Origin: NOD/ShiLtDvs

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IghH280)48Dvs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh (MGI:96442)

• Mutation details: The transgenic construct contains Ighm (IgM) and Ighd (IgD) heavy chain genes of islet-derived peripherin-specific B cell hybridoma H280. The transgene also contains a constant region component allowing expression of PerH as an IgM/D isotype of the IgHa allotype rather than an IgHb allotype naturally characterizing NOD mice. (J:274578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:274578 Leeth CM, et al., B-lymphocytes expressing an Ig specificity recognizing the pancreatic ss-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice. Diabetes. 2016 Jul;65(7):1977-1987
• All: 2 reference(s)