Slc1a2^tm1.1Pros
Targeted Allele Detail

Summary

• Symbol: Slc1a2^tm1.1Pros
• Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2; targeted mutation 1.1, Paul A Rosenberg
• MGI ID: MGI:5752263
• Synonyms: GLT-1^flox
• Gene: Slc1a2 Location: Chr2:102489004-102621129 bp, + strand Genetic Position: Chr2, 54.13 cM
• Alliance: Slc1a2^tm1.1Pros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221590
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 217 bp (2:102739471) upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted 419 bp (2:102740358-102740394) downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 4 floxed. (J:221590)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc1a2 Mutation: 40 strains or lines available

References

• Original: J:221590 Petr GT, et al., Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015 Apr 1;35(13):5187-201
• All: 9 reference(s)