Raet1e^em1Dhr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Raet1e^em1Dhr
• Name: retinoic acid early transcript 1E; endonuclease-mediated mutation 1, David H Raulet
• MGI ID: MGI:5752306
• Gene: Raet1e Location: Chr10:22034441-22059820 bp, + strand Genetic Position: Chr10, 9.89 cM
• Alliance: Raet1e^em1Dhr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 was used to induce a frameshift mutation in exon 2. Mutations were created in cis in both this gene and Raet1d, Raet1d^em1Dhr (J:221188)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Raet1e Mutation: 13 strains or lines available

References

• Original: J:221188 Deng W, et al., Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science. 2015 Apr 3;348(6230):136-9
• All: 2 reference(s)