Cxxc1^tm2.1Skk
Targeted Allele Detail

Summary

• Symbol: Cxxc1^tm2.1Skk
• Name: CXXC finger protein 1; targeted mutation 2.1, David G Skalnik
• MGI ID: MGI:5752623
• Synonyms: Cfp1^F, Cfp1-floxed, Cxxc1-flox
• Gene: Cxxc1 Location: Chr18:74349283-74354564 bp, + strand Genetic Position: Chr18, 50.7 cM
• Alliance: Cxxc1^tm2.1Skk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225690
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 2. A third loxP site was inserted downstream of exon 14. Cre-mediated recombination removed the selection cassette and left exons 2 through 14 floxed. (J:225690)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxxc1 Mutation: 28 strains or lines available

References

• Original: J:225690 Chun KT, et al., The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis. PLoS One. 2014;9(12):e113745
• All: 3 reference(s)