Sprtn^tm1.2Yjm
Targeted Allele Detail

Summary

• Symbol: Sprtn^tm1.2Yjm
• Name: SprT-like N-terminal domain; targeted mutation 1.2, Yuichi J Machida
• MGI ID: MGI:5752656
• Gene: Sprtn Location: Chr8:125624625-125632900 bp, + strand Genetic Position: Chr8, 72.83 cM
• Alliance: Sprtn^tm1.2Yjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225198
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. (J:225198)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sprtn Mutation: 13 strains or lines available

References

• Original: J:225198 Maskey RS, et al., Spartan deficiency causes genomic instability and progeroid phenotypes. Nat Commun. 2014;5:5744
• All: 2 reference(s)