Disc1^m1H
Chemically induced Allele Detail

Summary

• Symbol: Disc1^m1H
• Name: disrupted in schizophrenia 1; mutation 1, Harwell
• MGI ID: MGI:5752777
• Synonyms: DISC1^D453G, Disc1^enu1H
• Gene: Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
• Alliance: Disc1^m1H page

Mutation origin

• Strain of Origin: BALB/cAnN

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G point mutation that results in the amino acid substitution of glycine for aspartic acid at position 453 (D453G). (J:229661)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disc1 Mutation: 69 strains or lines available

References

• Original: J:229661 Dachtler J, et al., Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta signaling and sex-dependent behavioral effects in mice. Sci Rep. 2016;6:18748
• All: 1 reference(s)