Tg(Myh6*/tetO-FXYD1*S68E)39Jych
Transgene Detail

Summary

• Symbol: Tg(Myh6*/tetO-FXYD1*S68E)39Jych
• Name: transgene insertion 39, Joseph Y Cheung
• MGI ID: MGI:5752796
• Synonyms: PLM S68E TG
• Transgene: Tg(Myh6*/tetO-FXYD1*S68E)39Jych Location: unknown
• Alliance: Tg(Myh6*/tetO-FXYD1*S68E)39Jych page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6*/tetO-FXYD1*S68E)39Jych expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  dog	FXYD1 (476487)

• Mutation details: This transgene was designed with 279 bp of the mutant dog Fxyd1 gene (harboring an amino acid substitution of serine to glutamic acid at codon 68) plus the 5' and 3' untranslated sequences driven by a modified mouse alpha-myosin heavy chain minimal promoter (Myh6) fused with tetracycline responsive element (TRE or tetO). Founder line 39 was characterized. (J:182365)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:182365 Song J, et al., Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger. Am J Physiol Heart Circ Physiol. 2012 Feb;302(3):H770-81
• All: 2 reference(s)