Htra2^tm1.2Hohj
Targeted Allele Detail

Summary

• Symbol: Htra2^tm1.2Hohj
• Name: HtrA serine peptidase 2; targeted mutation 1.2, Josephine Hoh
• MGI ID: MGI:5752863
• Synonyms: HTRA2 KO
• Gene: Htra2 Location: Chr6:83028247-83031552 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Htra2^tm1.2Hohj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225666
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 4. Western blotting confirmed loss of protein in brain, spleen, and thymus tissues from homozygous mutant mice. (J:225666)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htra2 Mutation: 19 strains or lines available

References

• Original: J:225666 Patterson VL, et al., Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. PLoS One. 2014;9(12):e115789
• All: 1 reference(s)