Ntn1^tm1.1Tek
Targeted Allele Detail

Summary

• Symbol: Ntn1^tm1.1Tek
• Name: netrin 1; targeted mutation 1, Timothy E Kennedy
• MGI ID: MGI:5752940
• Synonyms: Netrin-1^flox
• Gene: Ntn1 Location: Chr11:68100190-68277652 bp, - strand Genetic Position: Chr11, 41.45 cM, cytoband B3
• Alliance: Ntn1^tm1.1Tek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227232
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains a FRT-flanked Neo selection cassette and a loxP site inserted downstream of the first protein coding exon of the targeted gene, and another loxP site was inserted upstream of the first protein coding exon. FLP-mediated recombination removed the FRT-flanked neo cassette. (J:227232)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntn1 Mutation: 106 strains or lines available

References

• Original: J:227232 Bin JM, et al., Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death. Cell Rep. 2015 Aug 18;12(7):1099-106
• All: 10 reference(s)