Lmr28e^CcS16/Dem
QTL Variant Detail

Summary

• QTL variant: Lmr28e^CcS16/Dem
• Name: leishmaniasis resistance 28e; CcS16/Dem
• MGI ID: MGI:5752964
• QTL: Lmr28e Location: Chr2:150144911-150145058 bp Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: CcS16/Dem

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: An interaction bewteen homozygous BALB/c alleles Lmr28e and Lmr12 were associated with higher TNF alpha levels in serum post infection. Lower levels were detected when homozygous STS/S alleles were at both loci. (J:108764)

References

• Original: J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• All: 1 reference(s)