Cd84^tm1Beni
Targeted Allele Detail

Summary

• Symbol: Cd84^tm1Beni
• Name: CD84 antigen; targeted mutation 1, Bernhard Nieswandt
• MGI ID: MGI:5753066
• Synonyms: Cd84^-
• Gene: Cd84 Location: Chr1:171667265-171718285 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Cd84^tm1Beni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225659
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced the splice donor site of exon 1, the complete intron 1, and a critical part of exon 2 (comprising parts of the 5' UTR, the translation initiation site and the coding sequence of the signal peptide). Western blot analysis and flow cytometry confirmed the absence of protein expression in platelets. (J:225659)

Generation of the Cd84^tm1Beni allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd84 Mutation: 54 strains or lines available

References

• Original: J:225659 Hofmann S, et al., Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis. PLoS One. 2014;9(12):e115306
• All: 1 reference(s)