Tac2^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Tac2^tm1Tigm
• Name: tachykinin 2; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5754397
• Synonyms: Tac2^bGeo
• Gene: Tac2 Location: Chr10:127560347-127567637 bp, + strand Genetic Position: Chr10, 74.81 cM, cytoband D3
• Alliance: Tac2^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223528
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-neomycin resistance cassette replaced exons 1 and 2. Immunohistochemistry confirmed the absence of protein expression in the arcuate nucleus of ovariectomized female mice. (J:223528)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tac2 Mutation: 18 strains or lines available

References

• Original: J:223528 True C, et al., Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. Endocrinology. 2015 Apr;156(4):1386-97
• All: 4 reference(s)