Grm6^nob8
Spontaneous Allele Detail

Summary

• Symbol: Grm6^nob8
• Name: glutamate receptor, metabotropic 6; no b wave 8
• MGI ID: MGI:5754533
• Gene: Grm6 Location: Chr11:50741512-50757035 bp, + strand Genetic Position: Chr11, 30.93 cM
• Alliance: Grm6^nob8 page

Mutation origin

• Strain of Origin: CBA/CaJ

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Single point mutation
• Mutation details: This spontaneous A-to-T transversion at position Chr11:50851337 (GRCm38) results in a missense mutation at position 66, changing methionine to leucine (p.M66L). This residue lies in the glutamate binding region and is invariant across many mammals including human. (J:240996)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm6 Mutation: 53 strains or lines available

References

• Original: J:240996 Peachey NS, et al., A MISSENSE MUTATION IN GRM6 REDUCES BUT DOES NOT ELIMINATE MGLUR6 EXPRESSION OR ROD DEPOLARIZING BIPOLAR CELL FUNCTION. J Neurophysiol. 2017 May 10;:jn.00888.2016
• All: 5 reference(s)