Nlgn1^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Nlgn1^tm1.1Sud
• Name: neuroligin 1; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:5754559
• Synonyms: NL1 cKO, NL1^fl
• Gene: Nlgn1 Location: Chr3:25480379-26386609 bp, - strand Genetic Position: Chr3, 10.38 cM, cytoband A3
• Alliance: Nlgn1^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227671
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 7. A FRT-flanked neomycin (neo) resistance cassette was inserted into intron 6 and a frt-flanked puromycin (puro) resistance cassette was inserted into intron 7. Flp-mediated recombination removed the FRT-flanked neo and puro cassettes leaving exon 7 floxed. (J:227671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlgn1 Mutation: 66 strains or lines available

References

• Original: J:227671 Zhang B, et al., Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 2015 Aug 19;87(4):781-96
• All: 6 reference(s)