Bcas1^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bcas1^em1(IMPC)Tcp
• Name: brain enriched myelin associated protein 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:5754586
• Gene: Bcas1 Location: Chr2:170188911-170269765 bp, - strand Genetic Position: Chr2, 91.41 cM
• Alliance: Bcas1^em1(IMPC)Tcp page
• IMPC: Bcas1 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele produced from project TCPR0256 at The Centre for Phenogenomics by injecting Cas9 mRNA and one guide RNA with the spacer sequence GGTGCCAATGGGCCGGTGGC. This resulted in an insertion of 1 bp (A on the -1 strand) at Chr2:170406531 (GRCm38) in exon 4 (ENSMUSE00001221352). This mutation is predicted to cause a frameshift with amino acid changes after residue 169 and early truncation 6 amino acids later (p.T170Nfs*8). (J:165963)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcas1 Mutation: 40 strains or lines available

References

• Original: J:165963 Centre for Modeling Human Disease, Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto. MGI Direct Data Submission. 2010
• All: 4 reference(s)