Lmr12c^CcS16/Dem
QTL Variant Detail

Summary

• QTL variant: Lmr12c^CcS16/Dem
• Name: leishmaniasis resistance 12c; CcS16/Dem
• MGI ID: MGI:5754778
• QTL: Lmr12c Location: Chr16:45792813-45792952 bp Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: CcS16/Dem

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Lmr12c interacts with Lmr19 on chromosome 10. Homozygosity for STS/A alleles at Lmr12c combined with homozygosity for BALB/cHeA alleles at Lmr19 confers increased spontaneous proliferation of spleen cells from Leishmania-infected mice. Each locus individually has minimal effect.

References

• Original: J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• All: 1 reference(s)