Grm6^nob7
Spontaneous Allele Detail

Summary

• Symbol: Grm6^nob7
• Name: glutamate receptor, metabotropic 6; no b wave 7
• MGI ID: MGI:5754842
• Gene: Grm6 Location: Chr11:50741512-50757035 bp, + strand Genetic Position: Chr11, 30.93 cM
• Alliance: Grm6^nob7 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: This spontaneous G-to-A point transition at the last position in exon 8 affects splice donor G-GT by changing it to A-GT. This results in the use of a cryptic splice donor A-GT 28 bp downstream. The resulting 3' extension of exon 8 by 28 bp results in a frameshift. Immunohistochemistry does not detect this protein in the dendritic tips of depolarizing bipolar cells in the retina indicating that this is a null allele. (J:229885)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm6 Mutation: 53 strains or lines available

References

• Original: J:229885 Qian H, et al., Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness. Vis Neurosci. 2015 Jan;32:E004
• All: 2 reference(s)