Satb2^em3(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Satb2^em3(IMPC)Tcp
• Name: special AT-rich sequence binding protein 2; endonuclease-mediated mutation 3, The Centre for Phenogenomics
• MGI ID: MGI:5755082
• Gene: Satb2 Location: Chr1:56833140-57017809 bp, - strand Genetic Position: Chr1, 28.72 cM
• Alliance: Satb2^em3(IMPC)Tcp page
• IMPC: Satb2 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele produced from project TCPR0329 at TCP by injecting Cas9 mRNA and one guide RNA with spacer sequence GGCTGCCGCTTCTTCGGTCG. This resulted in a 32 bp deletion from Chr1:56969761 to 56969792 (GRCm38) in ENSMUSE00000475062. This mutation is predicted to cause a frameshift with amino acid changes after residue 12 and early truncation 48 amino acids later (p.D12Rfs*50). (GRCm38). (J:165963)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Satb2 Mutation: 43 strains or lines available

References

• Original: J:165963 Centre for Modeling Human Disease, Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto. MGI Direct Data Submission. 2010
• All: 4 reference(s)