Tox3^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tox3^em1(IMPC)Tcp
• Name: TOX high mobility group box family member 3; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:5755092
• Gene: Tox3 Location: Chr8:90973668-91074971 bp, - strand Genetic Position: Chr8, 43.96 cM
• Alliance: Tox3^em1(IMPC)Tcp page
• IMPC: Tox3 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele produced from project TCPR0331 at TCP by injecting Cas9 mRNA and one guide RNA with the spacer sequence GGGAAGGCAACGGATCGCTG. This resulted in a 4 bp deletion from Chr8:90270347 to 90270350 in ENSMUSE00000331868. This mutation is predicted to cause a frameshift with amino acid changes after residue 96 and early truncation 53 amino acids later (p.S96Rfs*55). (GRCm38). (J:165963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tox3 Mutation: 38 strains or lines available

References

• Original: J:165963 Centre for Modeling Human Disease, Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto. MGI Direct Data Submission. 2010
• All: 4 reference(s)