Ctnnal1^tm1.1Sjm
Targeted Allele Detail

Summary

• Symbol: Ctnnal1^tm1.1Sjm
• Name: catenin alpha like 1; targeted mutation 1.1, Sean Morrison
• MGI ID: MGI:5755098
• Synonyms: alpha-catulin-GFP
• Gene: Ctnnal1 Location: Chr4:56810935-56865188 bp, - strand Genetic Position: Chr4, 31.66 cM, cytoband C1
• Alliance: Ctnnal1^tm1.1Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229960
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the exon 1 coding region and the exon 1 to intron 1 junction is replaced by an in-frame EGFP-bGH-pA-FRT-neo-FRT cassette via homologous recombination. Flp-mediated recombination removed the FRT-flanked neo cassette. Although predicted to be a loss-of-function allele, both heterozygous and homozygous mice exhibit no obvious phenotypic abnormalities. (J:229960)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctnnal1 Mutation: 176 strains or lines available

References

• Original: J:229960 Acar M, et al., Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature. 2015 Oct 1;526(7571):126-30
• All: 4 reference(s)