About   Help   FAQ
Lmr20bBALB/cHeA
QTL Variant Detail
Summary
QTL variant: Lmr20bBALB/cHeA
Name: leishmaniasis resistance 20b; BALB/cHeA
MGI ID: MGI:5755117
QTL: Lmr20b  Location: Chr1:175468817-175468938 bp  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  BALB/cHeA
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    BALB/c alleles were associated with higher IgE serum levels at Lmr20b. (J:152405)
Notes

Candidate Genes

J:152405

Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are:

Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM;

Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM;

Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM;

Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM;

and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.]

Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are:

Tir3c, trypanosome infection response 3c at 93.0 cM;

Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM;

Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM;

and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].

References
Original:  J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory