Lmr20c^STS/A
QTL Variant Detail

Summary

• QTL variant: Lmr20c^STS/A
• Name: leishmaniasis resistance 20c; STS/A
• MGI ID: MGI:5755122
• Synonyms: Lmr20c^CcS11/Dem
• QTL: Lmr20c Location: Chr1:175468817-175468938 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• The highest level of IFN gamma was observed in STS/A homozygotes at both Lmr20c and Lmr23. (J:152405)

Notes

Candidate Genes

J:152405

Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are:

Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM;

Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM;

Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM;

Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM;

and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.]

Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are:

Tir3c, trypanosome infection response 3c at 93.0 cM;

Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM;

Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM;

and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].

References

• Original: J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33
• All: 1 reference(s)