Lmr21b^STS/A
QTL Variant Detail

Summary

• QTL variant: Lmr21b^STS/A
• Name: leishmaniasis resistance 21b; STS/A
• MGI ID: MGI:5755162
• Synonyms: Lmr21b^CcS11/Dem
• QTL: Lmr21b Location: Chr7:127967235-127967336 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: The lowest levels of IFN gamma were observed in either STS/A homozygotes at both Lmr21b and Lmr32e or in BALB/c homozygotes at both loci. (J:152405)

Notes

Candidate Genes

J:152405

A potential candidated gene mapping near Lmr21, Lmr21a and Lmr21b which mapped to D7Mit67 at 63.5 cM on Chromosome 7 of CcS11/Dem in this study is:

Il4ra, interleukin 4 receptor, alpha at 62.0 cM. [Table 9.]

Possibly related QTL controlling other infections and co-localizing with the Lmr21 QTL are:

Tria4, T cell receptor induced activation 4 at 46.0 cM;

Heal6, wound healing/regeneration 6 at 52.4 cM;

Tsiq1, T cell secretion of IL4 QTL 1 at 59.0 cM;

and Dice2, determination of interleukin 4 commitment 2 at 63.5 cM [Table 10.]

References

• Original: J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33
• All: 1 reference(s)