Klrb1b^tm1.1Apma
Targeted Allele Detail

Summary

• Symbol: Klrb1b^tm1.1Apma
• Name: killer cell lectin-like receptor subfamily B member 1B; targeted mutation 1.1, Andrew P Makrigiannis
• MGI ID: MGI:5755236
• Synonyms: Nkrp1b^lox
• Gene: Klrb1b Location: Chr6:128790669-128803278 bp, - strand Genetic Position: Chr6, 63.09 cM, cytoband F3
• Alliance: Klrb1b^tm1.1Apma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222057
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region encompassing exons 2 - 5 was replaced with a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:222057)

Tumor Data

List all tumor models in MMHCdb carrying Klrb1b^tm1.1Apma

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klrb1b Mutation: 11 strains or lines available

References

• Original: J:222057 Rahim MM, et al., The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses. Blood. 2015 Apr 2;125(14):2217-27
• All: 3 reference(s)