Ppp2ca^tm1.2Jmli
Targeted Allele Detail

Summary

• Symbol: Ppp2ca^tm1.2Jmli
• Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; targeted mutation 1.2, Jianmin Li
• MGI ID: MGI:5755280
• Synonyms: Ppp2ca^-
• Gene: Ppp2ca Location: Chr11:51989651-52013576 bp, + strand Genetic Position: Chr11, 31.86 cM
• Alliance: Ppp2ca^tm1.2Jmli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222054
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 2. (J:222054)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2ca Mutation: 25 strains or lines available

Notes

ES cell line = C129

References

• Original: J:222054 Pan X, et al., Ppp2ca knockout in mice spermatogenesis. Reproduction. 2015 Apr;149(4):385-91
• All: 1 reference(s)