Naipc^tm1.1Kmma
Targeted Allele Detail

Summary

• Symbol: Naipc^tm1.1Kmma
• Name: NLR family, apoptosis inhibitory protein cluster; targeted mutation 1.1, Kendle M Maslowski
• MGI ID: MGI:5755387
• Synonyms: Naip1-6^delta
• Gene: Naipc Location: unknown Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Naipc^tm1.1Kmma involves 8 genes/genome features (Naip2, Naip1-rs1, Naip5 ...) View all
• Mutation details: A floxed pgk-neo cassette was inserted centromeric of Naip2 and a floxed pgk-hygro was inserted telomeric of Naip1 via sequential targeting events. Cre mediated recombination removed the entire genomic region between Smn1 and Gtf2h2 (J:222114)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Naipc Mutation: 0 strains or lines available

References

• Original: J:222114 Allam R, et al., Epithelial NAIPs protect against colonic tumorigenesis. J Exp Med. 2015 Mar 9;212(3):369-83
• All: 1 reference(s)