Dynll1^tm1.1Jhh
Targeted Allele Detail

Summary

• Symbol: Dynll1^tm1.1Jhh
• Name: dynein light chain LC8-type 1; targeted mutation 1.1, Jorg Heierhorst
• MGI ID: MGI:5755433
• Synonyms: Dynll1^fl
• Gene: Dynll1 Location: Chr5:115435129-115438995 bp, - strand Genetic Position: Chr5, 56.04 cM, cytoband F
• Alliance: Dynll1^tm1.1Jhh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230105
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The promoter, exon 1 and exon 2 were floxed. Flp-mediated recombination removed the puromycin resistance cassette and left and FRT site upstream of the second loxP site in intron 2. (J:230105)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Dynll1 Mutation: 20 strains or lines available

References

• Original: J:230105 Wong DM, et al., The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma. Cell Rep. 2016 Feb 16;14(6):1488-99
• All: 2 reference(s)