Brd7^tm1.2Ligy
Targeted Allele Detail

Summary

• Symbol: Brd7^tm1.2Ligy
• Name: bromodomain containing 7; targeted mutation 1.2, Guiyuan Li
• MGI ID: MGI:5755484
• Gene: Brd7 Location: Chr8:89057667-89088822 bp, - strand Genetic Position: Chr8, 43.07 cM, cytoband C4
• Alliance: Brd7^tm1.2Ligy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223952
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted an FRT-flanked neomycin resistance cassette with a 3' loxP site upstream of exon 3 and a second loxP site downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed the floxed exons 3 and 4. (J:223952)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brd7 Mutation: 32 strains or lines available

References

• Original: J:223952 Xu Y, et al., Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex. Behav Brain Res. 2015 Jun 1;286:1-10
• All: 3 reference(s)