Adgrb1^tm1Egvm
Targeted Allele Detail

Summary

• Symbol: Adgrb1^tm1Egvm
• Name: adhesion G protein-coupled receptor B1; targeted mutation 1, Erwin G Van Meir
• MGI ID: MGI:5755487
• Synonyms: Bai1^-
• Gene: Adgrb1 Location: Chr15:74388045-74461314 bp, + strand Genetic Position: Chr15, 34.22 cM
• Alliance: Adgrb1^tm1Egvm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222100
• Parent Cell Line: HZ2.2 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 (containing the start codon ATG) was replaced with a lacZ-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous mutant brains. (J:222100)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrb1 Mutation: 77 strains or lines available

References

• Original: J:222100 Zhu D, et al., BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015 Apr;125(4):1497-508
• All: 2 reference(s)