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Otoglem1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Otoglem1(IMPC)J
Name: otogelin-like; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:5755623
Synonyms: Otoglem1J
Gene: Otogl  Location: Chr10:107596392-107747995 bp, - strand  Genetic Position: Chr10, 56.11 cM
Alliance: Otoglem1(IMPC)J page
IMPC: Otogl gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project Otogl-7415J-M363 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences TTTCTGAGATGGTCCCTTGG, GAGATGGTCCCTTGGTGGTG, CCATGATCGAGACCGTCTCG, and CCCGAGACGGTCTCGATCAT, which resulted in a 270 bp deletion spanning exon 4 beginning at Chromosome 10 negative strand position 107,903,262 bp, CCCCGAGACGGTCTCGATCA, and ending after TGAGATGGTCCCTTGGTGGT at 107,902,993 bp (GRCm38/mm10). This mutation deletes exon 4 and 203 bp of flanking intronic sequence including the splice acceptor and donor. This mutation is predicted to result in an amino acid sequence change after residue 47 and early truncation 119 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otogl Mutation:  136 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory