Bpq11^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bpq11^C57BL/6J
• Name: blood pressure QTL 11; C57BL/6J
• MGI ID: MGI:5755973
• QTL: Bpq11 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• At Bpq11 the C57BL/6J allele was associated with increased blood pressure. (J:148559)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:148559

The genetic variation underlying varaition in systolic blood pressure and heart rate were analyzed in a QTL study using 395 (C57BL/6J x DBA/2J)F2 mice (197 males, 198 females) and 22 BXD recombinant inbred (RI) strains.

Systolic blood pressure and heart rate were measured in F2 animals on seven separate occasions, four consecutive daily tests at 115 days, another test 1 week later, then twice more at four week intervals. RI mice were measured on five occasions, four consecutive daily tests and once the following week. Test groups consisted of 12-16 animals equally divided by sex.

F2 mice were genotyped with 96 microsatellite markers spaced at approximately 15 to 20 cM intervals throughout the genome. Interval mapping analysis and a genome wide scan for epistatic interactions between all pairs of autosomal markers in the intercross was carried out using J/qtl and R/qtl packages.Thresholds were obtained for an F2 intercoss via 10,000 simualtions by the developes of R/qtl. Sex, suggestive, or significant QTL and epistatic interactions were included in a multiple regression model for each trait.

Three suggestive QTL were identified for systolic blood preassure on chromosomes 14, 8 and 3.

Bpq11, blood pressure QTL 11 mapped to Chr 14, LOD=3.4 at 31 cM mapping nearest marker D14Mit203 with a 95% confidence interval between 10-42 cM. At Bpq11 the C57BL/6J allele was associated with increased blood pressure and accounted for 1.9 % of trait variance.

Bpq12, blood pressure QTL 12 mapped to Chr 8, LOD=4.2 at 37 cM mapping nearest marker D8Mit249 with a 95% confidence interval bewteen 27-46 cM. At Bpq12 the DBA/2J allele was associated with increased blood pressure and accounted for 4.0% of trait variance.

Bpq13, blood pressure QTL 13, was a female specific QTL mapped to Chr 3, LOD=3.5 at 58.5 cM mapping nearest marker D3Mit42 with a 95% confidence interval bewteen 49-65 cM. At Bpq13 the C57BL/6J allele was associated with increased blood pressure and accounted for 4.5% of trait variance.

References

• Original: J:148559 Blizard DA, et al., Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics. 2009 Feb 2;36(3):158-66
• All: 1 reference(s)