Tg(BEST1-HTRA1)44Ybf
Transgene Detail

Summary

• Symbol: Tg(BEST1-HTRA1)44Ybf
• Name: transgene insertion 44, Yingbin Fu
• MGI ID: MGI:5758950
• Synonyms: hHTRA1+ Tg44
• Transgene: Tg(BEST1-HTRA1)44Ybf Location: unknown
• Alliance: Tg(BEST1-HTRA1)44Ybf page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(BEST1-HTRA1)44Ybf expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTRA1 (5654)

  Htra1

  (MGI:1929076)

• Tg(BEST1-HTRA1)44Ybf expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  BEST1 (7439)

  Best1

  (MGI:1346332)

• The human HTRA1 cDNA is under the control of the human VMD2 promoter. (J:175227, J:230011)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Polypoidal Choroidal Vasculopathy J:230011.

References

• Original: J:230011 Kumar S, et al., Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2014 Jun;55(6):3842-50
• All: 3 reference(s)