Eef2k^tm1.1Cgpd
Targeted Allele Detail

Summary

• Symbol: Eef2k^tm1.1Cgpd
• Name: eukaryotic elongation factor-2 kinase; targeted mutation 1.1, Christopher G Proud
• MGI ID: MGI:5759976
• Gene: Eef2k Location: Chr7:120442080-120506441 bp, + strand Genetic Position: Chr7, 64.95 cM, cytoband F3
• Alliance: Eef2k^tm1.1Cgpd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neomycin resistance cassette with a 3'loxP site was inserted downstream of exon 10. Cre-mediated recombination removed exons 7 through 10 along with the selection cassette. (pers comm)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef2k Mutation: 43 strains or lines available

References

• Original: J:224568 Wang X, et al., Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity. Biochem J. 2015 Apr 15;467(2):321-31
• All: 7 reference(s)