Tg(PRNP)45Jcol
Transgene Detail

Summary

• Symbol: Tg(PRNP)45Jcol
• Name: transgene insertion 45, John Collinge
• MGI ID: MGI:5760245
• Synonyms: 129MM Tg45, Tg(HuPrP129M)
• Transgene: Tg(PRNP)45Jcol Location: unknown
• Alliance: Tg(PRNP)45Jcol page

Transgene origin

• Strain of Origin: mixed

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PRNP)45Jcol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRNP (5621)

  Prnp	(MGI:97769)

• Tg(PRNP)45Jcol expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  PRNP (5621)

  Prnp	(MGI:97769)

• Mutation details: This transgene consists of the human PRNP with methionine at codon 129, a polymorphism determining susceptibility to sporadic and acquired prion diseases. (J:131494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This transgene was originally microinjected into Prnp^tm1Cwe oocytes. Oocytes of mixed background involve: 129 * C57BL/6 * FVB/N.

References

• Original: J:131494 Asante EA, et al., BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. EMBO J. 2002 Dec 2;21(23):6358-66
• All: 1 reference(s)