Bag3^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Bag3^{tm1c(EUCOMM)Hmgu}
• Name: BCL2-associated athanogene 3; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5760384
• Gene: Bag3 Location: Chr7:128125340-128148705 bp, + strand Genetic Position: Chr7, 70.26 cM
• Alliance: Bag3^{tm1c(EUCOMM)Hmgu} page
• IMPC: Bag3 gene page

Dilated cardiomyopathy in Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(Myhca-cre)1Abel/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: HEPD0556_7_B06
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Flp-mediated excision of the parental Bag3^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bag3 Mutation: 31 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 7 reference(s)