Appl2^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Appl2^tm1Smoc
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:5762674
• Synonyms: APPL2^floxed, Appl2^tm1Srcmo
• Gene: Appl2 Location: Chr10:83435897-83484602 bp, - strand Genetic Position: Chr10, 41.29 cM
• Alliance: Appl2^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230004
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked with loxP sites. An FRT-flanked neomycin resistance cassette was inserted upstream of the loxP sites. (J:230004)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Appl2 Mutation: 27 strains or lines available

References

• Original: J:230004 Cheng KK, et al., The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes. 2014 Nov;63(11):3748-58
• All: 4 reference(s)