Smap2^tm1Sata
Targeted Allele Detail

Summary

• Symbol: Smap2^tm1Sata
• Name: small ArfGAP 2; targeted mutation 1, Masanobu Satake
• MGI ID: MGI:5762694
• Gene: Smap2 Location: Chr4:120825514-120874444 bp, - strand Genetic Position: Chr4, 56.7 cM
• Alliance: Smap2^tm1Sata page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230490
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ reporter gene and neomycin resistance cassette replaced the 3' portion of exon 1. Western blot analysis confirmed the absence of protein expression in brain and testis lysates. (J:230490)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smap2 Mutation: 23 strains or lines available

References

• Original: J:230490 Funaki T, et al., The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis. Mol Biol Cell. 2013 Sep;24(17):2633-44
• All: 2 reference(s)