Ywhae^tm2.1Awb
Targeted Allele Detail

Summary

• Symbol: Ywhae^tm2.1Awb
• Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; targeted mutation 2.1, Anthony Wynshaw-Boris
• MGI ID: MGI:5762859
• Synonyms: 14-3-3epsilon^fl, Ywhae^flox
• Gene: Ywhae Location: Chr11:75623695-75656671 bp, + strand Genetic Position: Chr11, 45.92 cM, cytoband B2
• Alliance: Ywhae^tm2.1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216299
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3 and a second loxP site downstream of exon 4 followed by an FRT-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:216299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ywhae Mutation: 65 strains or lines available

References

• Original: J:216299 Toyo-oka K, et al., 14-3-3epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014 Sep 3;34(36):12168-81
• All: 7 reference(s)