Epyc^tm1Mhok
Targeted Allele Detail

Summary

• Symbol: Epyc^tm1Mhok
• Name: epiphycan; targeted mutation 1, Magnus Hook
• MGI ID: MGI:5762921
• Gene: Epyc Location: Chr10:97479930-97517770 bp, + strand Genetic Position: Chr10, 50.35 cM, cytoband C2-C3
• Alliance: Epyc^tm1Mhok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222369
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting constructs introduced into exon 3 6 bp downstream of the translation initiation sequence a lacZ reporter gene and a floxed neomycin resistance cassette. Immunohistochemistry confirmed the absence of protein expression in the knee joint. (J:222369)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epyc Mutation: 21 strains or lines available

References

• Original: J:222369 Nuka S, et al., Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage. 2010 Jan;18(1):88-96
• All: 1 reference(s)