Tgfb1i1^tm1.1Knos
Targeted Allele Detail

Summary

• Symbol: Tgfb1i1^tm1.1Knos
• Name: transforming growth factor beta 1 induced transcript 1; targeted mutation 1.1, Kiyoshi Nose
• MGI ID: MGI:5762965
• Gene: Tgfb1i1 Location: Chr7:127845963-127852884 bp, + strand Genetic Position: Chr7, 70.07 cM, cytoband F1-F3
• Alliance: Tgfb1i1^tm1.1Knos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223628
• Parent Cell Line: Baltha1 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1'. A floxed neomycin resistance cassette was inserted downstream of exon 10. Cre-mediated recombination removed exon 1' through exon 10. Western blot analysis confirmed the absence of protein expression in lungs and aortic vascular smooth muscle cells. (J:223628)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfb1i1 Mutation: 23 strains or lines available

References

• Original: J:223628 Kim-Kaneyama JR, et al., Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling. J Mol Cell Cardiol. 2011 Jan;50(1):77-86
• All: 7 reference(s)